Thyroid Hormone

Skeletal effects of nongenomic thyroid hormone receptor beta signaling

Thyroid hormone (TH) levels increase rapidly during the prepubertal growth period in mice, and this change is necessary for endochondral ossification of the epiphyses. This effect of TH on epiphyseal chondrocyte hypertrophy is mediated via TRβ1. In …

Thyroid hormone acting via TRβ induces expression of browning genes in mouse bone marrow adipose tissue

**PURPOSE**: Mutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent …