Vitamin C (ascorbic acid, AA) is a well-known regulator of bone and cartilage metabolism. However, the mechanisms of AA's action in these tissues are only partly understood. In this study, we confirmed that AA contributes to bone and cartilage …
Thyroid hormone (TH) levels increase rapidly during the prepubertal growth period in mice, and this change is necessary for endochondral ossification of the epiphyses. This effect of TH on epiphyseal chondrocyte hypertrophy is mediated via TRβ1. In …
The claudin (Cldn) family comprises 27 members of 20-34 kDa transmembrane tight junction proteins. In addition to their established canonical role as barriers controlling paracellular flow of molecules, a distinct non-canonical role for Cldns as …